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Cerebral cortical grey matter deficits in schizophrenia and their associations with ageing, psychopathology, cognition and treatment response.

Ulrich Schall

The diagnosis of schizophrenia lacks a broadly accepted biological basis and its heterogeneity may well represent a group of disorders with different aetiologies. Even so, brain imaging can map and quantify structural brain abnormalities in vivo as an intermediate (or endo-) phenotype of the disorder. To identify the degree of regional grey matter deficits in relation to age, the severity of psychopathology and cognitive/ neurological impairment, and treatment response in schizophrenia. Eighteen schizophrenia patients (32.2 years [SD 14.3], meeting DSM-IV criteria were examined. Eighteen pair-wise age (±2 years) and gender-matched healthy volunteers (31.9 years [SD 14.3]) served as control group.

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia.
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Ulrich Schall
Ulrich Schall
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Ulrich Schall

Professor Ulrich Schall University of Newcastle & Minds in Transition (MinT) Consortium

Co-authors: Presented on behalf of Dr Nishantha Kumarasinghe, P. Rasser, J. Mendis, A. Perera, S. Yasarwardene, P. Tooney
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