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Altered epidermal growth factor receptor levels in dorsolateral prefrontal cortex may be implicated in suicidality in schizophrenia.

Vaidy Swaminathan

Emerging evidence demonstrates dysregulation of the Epidermal Growth Factor (EGF) system in schizophrenia (SCZ) with increased levels of the EGF receptor (EGFR) and decreased levels of EGF in both brain and blood. We have shown clozapine transactivates EGFR to augment signalling and this may be related to its clinical effects. We examined EGFR in post-mortem human brain tissue from people with SCZ and healthy controls.

EGFR messenger RNA (mRNA) expression was measured by in-situ hybridization (ISH) and qRT-PCR and protein levels by Western blotting in dorsolateral pre frontal cortex (DLPFC) (BA46) from 37 persons with SCZ and 37 healthy controls. EGFR protein was significantly (p<0.04) increased in SCZ (1.63±1.15, mean±SD) compared to controls (1.218±0.21). 

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia
Visit MAPrc at: www.maprc.org.au

Vaidy Swaminathan
Vaidy Swaminathan
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VideoAltered epidermal growth factor receptor levels in dorsolateral prefrontal cortex may be implicated in suicidality in schizophrenia.Vaidy Swaminathan8'18"
icon pdf.gifAltered epidermal growth factor receptor levels in dorsolateral prefrontal cortex may be implicated in suicidality in schizophrenia.Vaidy Swaminathan 
icon mp3.gifAltered epidermal growth factor receptor levels in dorsolateral prefrontal cortex may be implicated in suicidality in schizophrenia.Vaidy Swaminathan 


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Vaidy Swaminathan

Vaidy Swaminathan is a PhD student at The Florey Institute of Neuroscience and Mental Health, Northern Psychiatry Research Centre,  Department of Psychiatry,
The University of Melbourne, Victoria, Australia and is involved with Schizophrenia Research Institute, Darlinghurst, NSW, Australia. 

Co-authors: Avril M Pereira, Shan Yuan Tsai­Chin, Cyndi Shannon-Weickert, Suresh Sundram,
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