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The Epidermal Growth Factor system in schizophrenia and its relation to treatment resistance

A/Professor Suresh Sundram

Up to 45% of patients with schizophrenia are treatment resistant to conventional drugs leaving clozapine as the only effective option. Its severe side-effects however limit it to a late stage option and the development of a biomarker to predict treatment response would be of high clinical utility. Our previous data demonstrate clozapine augments epidermal growth factor receptor (EGFR) signalling and hence we examined if EGF levels may be altered in treatment resistant schizophrenia (TRS) and are influenced by clozapine treatment. To determine if EGF levels are influenced by clozapine in TRS and can serve as a biomarker for clozapine response. Serum EGF levels were measured by ELISA in patients with TRS at baseline, 2, 6 and 26 weeks of clozapine treatment and in age and sexed matched healthy controls. Positive and Negative Syndrome Scale (PANSS) and CGI data were collected at baseline, 6 and 26 weeks.

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia.
Visit MAPrc at: www.maprc.org.au

Suresh Sundram
Suresh Sundram
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A/Professor Suresh Sundram

Suresh Sundram continues his work as an external consultant to the Australian Human Rights Commission on mental health issues and is currently preparing a report for the Commission on the mental health problems within Immigration Detention Centres. Suresh Sundram was appointed to the Executive of the World Psychiatric Association Section on Developing Countries, and was appointed Chair of the Scientific Committee of the 3rd World Congress of Asian Psychiatry.

Co-authors: Sinnatamby Sujeevan, Avril Pereira, Sumathy Sathiyamoorthy, Peter Malcolm
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