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Serum epidermal growth factor levels are reduced in people with treatment resistant schizophrenia and modulated by clozapine treatment.

Sinnatamby Sujeevan

Up to 45% of patients with schizophrenia are treatment resistant to conventional drugs leaving clozapine as the only effective option. Its severe side-effects however limit it to a late stage option and the development of a biomarker to predict treatment response would be of high clinical utility. Our previous data demonstrate clozapine augments epidermal growth factor receptor (EGFR) signaling and hence we examined if EGF levels may be altered in treatment resistant schizophrenia (TRS) and are influenced by clozapine treatment. Study objectives: To determine if EGF levels are influenced by clozapine in TRS and can serve as a biomarker for clozapine response.

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia.
Visit MAPrc at: www.maprc.org.au

Sinnatamby Sujeevan
Sinnatamby Sujeevan
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VideoSerum epidermal growth factor levels are reduced in people with treatment resistant schizophrenia and modulated by clozapine treatment.Sinnatamby Sujeevan8'15"
icon pdf.gifSerum epidermal growth factor levels are reduced in people with treatment resistant schizophrenia and modulated by clozapine treatment.Sinnatamby Sujeevan 
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Sinnatamby Sujeevan

Molecular Psychopharmacology, Florey Institute of Neuroscience and Mental Health, Northern Psychiatry Research Centre, Department of Psychiatry, University of Melbourne, VIC, Australia. 

Co-authors: Avril Pereira, Sumathy Sathiyamoorthy, Peter Malcolm, Suresh Sundram
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