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Interaction of maternal immune activation and adolescent cannabinoid exposure enhances changes in miRNA expression in the adult entorhinal cortex.

Sharon Hollins

Post-mortem analyses of cortical brain tissue in schizophrenia have been shown to display epigenetic changes that reflect early life experience. These affect the regulation of gene expression at the level of transcription, through changes in chromatin structure; and post-transcriptionally through non-coding RNAs, such as microRNA (miRNA). The aim of the current study was to investigate the role of miRNA in the brains’ response to maternal immune activation and adolescent cannabis exposure, alone and in combination, as both have been identified as environmental risk factors for schizophrenia.

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia.
Visit MAPrc at: www.maprc.org.au

Sharon Hollins
Sharon Hollins
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VideoInteraction of maternal immune activation and adolescent cannabinoid exposure enhances changes in miRNA expression in the adult entorhinal cortex.Sharon Hollins13'28"
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Sharon Hollins

Mrs Sharon Hollins is currently a PhD Candidate in Molecular Neurobiology at the University of Newcastle under the supervision of Conjoint Associate Professor Murray Cairns. Her current area of research investigates the role of post-transcriptional gene silencing in the mammalian brain's response to environmental stress during development and aging. In particular, focusing on the role of short, non-coding microRNA that are involved in the stability and translation of mRNA. Recent evidence suggests that these dynamic and influential molecules play an important role in both brain development and the cellular response to stress. Given the close relationship between miRNA, environmental stress and brain development, it is plausible that miRNA have a significant position at the molecular crossroads between neural development and the neurodevelopmental response to environmental stress.

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