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Omega-3 fatty acid supplementation effects phospholipase A2 activity in individuals at ultra-high risk of psychosis.

Paul Amminger

The dopamine system plays a crucial role in mediating cognitive and affective processes. Aberrant dopamine neurotransmission is also thought to underlie the symptoms of schizophrenia. Dopamine-dependent prefrontal response relies on the regulation of both dopamine availability and the relative balance of D1/D2 receptor mediated action. This study aimed to determine the extent to which the catechol-O-methyltransferase (COMT) val108/158met (rs4680) and dopamine D2 receptor (DRD2) G-T (rs2283265) polymorphisms combine additively to determine prefrontal brain activity during cognitive-affective processing in healthy people and in schizophrenia.

The identification of an ultra-high risk (UHR) profile for psychosis and a greater understanding of its prodrome have led to increasing interest in early intervention to delay or prevent the onset of psychotic illness. In a randomized placebo-controlled trial, we have identified long-chain omega-3 polyunsaturated fatty acid (PUFA) supplementation as potentially useful, as it reduced the rate of transition to psychosis by 22.6% 1 year after baseline in a cohort of 81 young people at UHR of transition to psychosis. However, the mechanisms whereby the omega-3 PUFAs might be neuroprotective are incompletely understood.  

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia.
Visit MAPrc at: www.maprc.org.au

Paul Amminger
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Paul Amminger

Dr G. Paul Amminger is Associate Professor at Orygen Youth Health Research Centre, Melbourne. His research spans from traditional high-risk research in schizophrenia to pioneering intervention studies during the onset phase of psychosis and recently in youth depression. He successfully tested the efficacy of omega-3 fatty acids in children with autism and in young people at ultra-high risk for psychosis. The publication of the study “Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial” in Archives of General Psychiatry has received substantial media attention and professional attention. http://www.optymise.org.au/about-optymise/people/chief-investigators/associate-professor-paul-amminger/

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