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Enhanced LTP Persistence Associated with Memory Alteration in the Maternal Immune Activation Model of Schizophrenia.

David Bilkey

Individuals with schizophrenia display a number of structural and cytoarchitectural alterations in the hippocampus, suggesting that functional processes such as synaptic plasticity may also be modified. Altered hippocampal plasticity is likely to affect memory function, and may therefore contribute to the cognitive symptoms of schizophrenia.  

Our goal was to determine whether environmental risk factors that have previously been associated with schizophrenia produced changes in hippocampal synaptic plasticity and associated memory processes, using the maternal immune activation (MIA) animal model. Pregnant rat dams were administered either Poly I:C or vehicle on GD15 to initiate MIA. Long-term potentiation (LTP) was measured in the dentate gyrus of their freely-moving, adult offspring. 

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia.
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David Bilkey
David Bilkey
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David Bilkey

Professor David Bilkey a PhD from the University of Otago in 1987. After working as a postdoctoral fellow at the University of Washington in 1988 he returned to Otago as a lecturer, and served as the Head of Department from 2009 to 2013.  Professor David Bilkey’s general research area is systems neuroscience, with a particular focus on the role of the temporal cortex regions of the brain in memory and learning processes. More recently he has been investigating how the function of the hippocampus is altered in schizophrenia using an animal model of the disorder. His research has been funded by the Health Research Council and Marsden Fund. He is an author on over 90 articles published in high-impact international journals and is actively involved in promoting science in schools. He is a past recipient of an Alexander von Humboldt Fellowship and has served on several major funding panels. www.otago.ac.nz/psychology/staff/davidbilkey.html 

Co-authors: Shakuntala SavanthrapadianAmy R. WolffBarbara J. Logan Michael J. EckertWickliffe C. Abraham
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