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Common polymorphisms in dopamine related genes combine to produce a “schizophrenia-like” prefrontal hypoactivity

Ashley Skilleter

The dopamine system plays a crucial role in mediating cognitive and affective processes. Aberrant dopamine neurotransmission is also thought to underlie the symptoms of schizophrenia. Dopamine-dependent prefrontal response relies on the regulation of both dopamine availability and the relative balance of D1/D2 receptor mediated action. This study aimed to determine the extent to which the catechol-O-methyltransferase (COMT) val108/158met (rs4680) and dopamine D2 receptor (DRD2) G-T (rs2283265) polymorphisms combine additively to determine prefrontal brain activity during cognitive-affective processing in healthy people and in schizophrenia.

12th Biennial Australasian Schizophrenia Conference
13-14 May 2013 Melbourne, Australia.
Visit MAPrc at: www.maprc.org.au

Ashley Skilleter
Ashley Skilleter
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VideoCommon polymorphisms in dopamine related genes combine to produce a “schizophrenia-like” prefrontal hypoactivityAshley Skilleter10'26"
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Ashley Skilleter

PhD Student at UNSW and NeuRA under the supervision of Dr Thomas Weickert and Professor Cyndi Shannon Weickert.

Co-authors: Presented by Ashley Skillet on behalf of Dr Thomas Weickert University of New South Wales
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